affinity maturation

Strategies for affinity maturation of engineering antibodies

基因工程抗体亲和力成熟的策略

In this review , the advance of antibody affinity maturation which is one of the important elements of antibody engineering is described .

而抗体工程发展所面临的两大难点问题之一就是如何提高基因工程抗体的亲和力。本文综述了有关基因工程抗体体外抗体亲和力成熟方面的最新进展。

Anti-Keratin Human Antibody : Gene Cloning , Expression and Affinity Maturation

人源性抗角蛋白抗体的基因克隆、表达及亲和力成熟

Conclusion Affinity maturation might have been completed by the time that patients presented with anti-GBM disease .

结论起病时抗GBM抗体的亲合力成熟过程已经完成。

Conclusion The results provided a model for the study of structure and function of antibody as well as antibody affinity maturation .

结论实验结果为抗血管内皮生长因子人源单链抗体的应用奠定了基础，同时为抗体结构与功能研究以及抗体亲和力体外成熟提供了参考模型。

Affinity Maturation of Human Anti-TNF - α Fab Through Constructing a Light Chain Second Library

通过构建轻链二级库对人源抗TNF-α抗体进行亲和力成熟

Affinity maturation of an anti-keratin human antibody by chain shuffling

链替换技术提高抗角蛋白人Fab抗体的亲和力

IN VITRO MATURATION OF PIG OOCYTES Affinity Maturation of a Single Chain Variable Fragment Antibody for Hepatocellular Carcinoma

猪卵母细胞的体外成熟抗肝癌单链抗体的体外亲和力成熟研究

In Vitro Affinity Maturation of an Anti-TNF α Antibody

抗TNFα抗体的体外亲和力成熟

Selection , Identification and Preliminary Study of Affinity Maturation of ScFv Specific Against A β _ ( 1-42 ) Oligomers

Aβ（1-42）寡聚体特异性scFv的筛选、鉴定和亲和力成熟的初步研究

Affinity maturation of a single-chain antibody for hepatocellular carcinoma by error-prone PCR and DNA shuffling

错配PCR和DNA改组技术提高抗肝癌单链抗体亲和力

A powerful computational implementation of the clonal selection principle that explicitly takes into account the affinity maturation of the immune response is proposed in this paper .

提出了一种执行克隆选择原则的强有力的计算方法，算法思想中考虑到在免疫响应产生的较高亲和力的抗体中，选择改进的成熟后代。

The algorithm is inspired by the mechanism in which a kind of antibody can identify multi-epitope of an antigen and gradually accomplish affinity maturation in the evolutionary process .

基于免疫细胞中不同亲和度抗体具有不同的变异率，最终通过不断进化达到亲和度成熟机理的启示，设计并实现了一个多模态免疫优化算法。

An artificial network structure ( aiNet ) stressing the clonal selection and affinity maturation and immune network theory was capable of reducing redundancy , describing data structure , including the shape of clusters .

利用免疫理论中的克隆选择、亲和力成熟和免疫网络理论来建构一种网络模型aiNet，将其用于数据聚类可以减少数据中的冗余，描述数据结构和聚类形状。

A novel intelligent optimization algorithm , suitable for function optimization problems , is proposed based on the ideas of T cell regulation , affinity maturation characteristics , the niche sharing fitness method , and some other immune mechanisms .

借鉴免疫系统中T细胞调节的思想、抗体重复变异的亲和成熟特征、小生境共享适应度方法及相关的免疫机制，提出一种适合于函数优化的新型智能优化算法。

The key of the algorithm is both to utilize T cell regulation mechanism for adjusting the size of antibodies participated in mutation , and design a self - adaptive mutation operator by using the affinity maturation mechanism .

算法设计的关键在于利用T细胞调节机制动态调节参与变异的抗体数目，以及利用抗体亲和成熟特征设计自适应突变的算子模块；

With the technology development , a diversity of engineered antibody forms have been created to improve their characterization and efficacy , including humanization of murine antibodies , enhancing their biological activities such as affinity maturation , improvement of effector functions , and altering pharmacokinetics .

随着技术的发展，各种形式的工程抗体被构建来改善它们的特性和效能，包括：鼠抗体人源化，提高生物学活性，如亲和力成熟，改进效应功能，改善药代动力学。